Last trade: INSM +141%
Biotech Catalyst Trading

176% Annualized.
54 Trades. Full Transparency.

FDA catalysts are asymmetric bets. I use Monte Carlo simulations, Kelly sizing, and historical approval data to find the ones worth taking—then publish every position, win or lose.

Get the next trade before I post it publicly. No spam, ever.

53%
Realized Return
(5 months)
29
Companies Traded
100%
Positions Disclosed
--
Community Members
live
// THE ENGINE

Quantitative Framework

10K
Simulations/Strike
140%
Min ENR Entry
45%+
Win Prob Floor
Half-K
Position Sizing
24/7
OI Monitoring
85%
PDUFA Base Rate
01

Catalyst Screening

Continuous monitoring of FDA calendar, clinical trial databases, and regulatory filings. Market cap filters ($400M-$5B), optimal timing windows (45-120 days), and priced-in risk detection.

02

Probability Engine

Monte Carlo simulations modeling stock moves, IV crush, and time decay. Historical FDA approval rates by phase, indication, and designation. Management track record analysis.

03

Smart Money Signals

Real-time Open Interest tracking with accumulation alerts. Put/call skew analysis, notional significance scoring, and institutional positioning detection.

Constantly Monitoring

FDA Calendar Open Interest IV Percentiles Management Track Records Clinical Trial Data Market Regime
The Problem

Most Biotech Trading is Gambling

The biotech options space is filled with hype, FOMO, and traders who treat FDA catalysts like lottery tickets.

Gut-Feel Decisions

Trading based on "feeling good" about a stock instead of calculated probabilities and expected returns.

Single-Event Gambling

All-in bets on one PDUFA date with no consideration of multiple catalysts or time diversification.

No Risk Management

Position sizes based on "conviction" rather than mathematical frameworks like Kelly Criterion.

Hidden Losses

Influencers who only show winners. No accountability, no learning, no real track record.

Sound familiar? There's a better way.

The PowersBioStrikes Approach

Engineering Meets Trading

A systematic, quantitative methodology built by an engineer who believes in math over hype. If the math doesn't work, I don't trade.

01

Expected Net Return

10,000 Monte Carlo simulations per strike. ENR threshold of 140%+ for new entries. IV crush modeling, time decay curves, and percentile analysis (5th-95th).

  • Historical FDA approval rates by phase
  • IV crush factors (30-60%)
  • Market cap move multipliers
02

Kelly Criterion Sizing

Mathematical position sizing: (Win% x Payout - Loss%) / Payout. Half-Kelly for volatility dampening. Tiered sizing: Heavy (>15%), Standard (8-15%), Light (3-8%).

  • Win probability from simulations
  • 95th percentile payouts
  • Portfolio concentration limits
03

Dual Strategy Approach

Single binary events for high-conviction PDUFA plays. Multi-catalyst LEAPs for free-rolling when the math aligns. 2-9 month horizons.

  • Binary event precision timing
  • LEAP free-roll strategy
  • Catalyst stacking when aligned
Full Transparency

Every Entry. Every Exit. Every Loss.

54 trades. 29 companies. Every position timestamped and published.
Because hiding losses isn't a strategy—it's a scam.

Recent Closed Trades

Showing 5 of 54
Ticker Position Entry Exit Return Catalyst
INSM Jan $60C $4.20 $10.15 +141% PDUFA Approval
CRNX Dec $15C $2.85 $6.10 +114% Phase 2 Data
IMVT Nov $35C $3.40 $0.85 -75% Phase 3 Miss
VKTX Jan $70C $5.50 $9.25 +68% Obesity Data
VRNA Dec $10C $1.20 $2.75 +129% RSV Results
Wins: 37
Losses: 17
|
Win Rate: 68.5%
View full track record with Founding Member access →

* All trades timestamped on entry. P&L calculated from actual fills. Losses shown prominently—because that's how you learn and build trust.

How This Works

The Portfolio Approach to Binary Events

This isn't about hitting home runs on every trade. It's about math, diversification, and accepting that losses are part of the game.

Total Losses Happen

When a catalyst misses or the FDA rejects, these options often go to zero. We try to exit for partial recovery when possible, but total loss is a normal outcome. This is expected, not a failure of the system.

10-20 Working Positions

The strategy requires diversification across multiple catalysts. No single trade should risk your portfolio. With 10-20 positions, the winners cover the losers and generate net positive returns over time.

The Math Works

A 60% win rate with +150% average winners and -80% average losers still generates strong returns. That's why position sizing and ENR calculations matter more than any single trade.

Know What You're Trading

Options trading requires understanding leverage and position sizing. Our systematic approach aims to put the odds in your favor through disciplined analysis and risk management. As with any investment, only use capital you've allocated for trading.

Live Positions

Current Active Trades

Here's what I'm holding right now. Real positions, real money, entered January 21, 2026.
This is what members see before I post publicly.

Data refreshes every 30 minutes during market hours

IMMP Oncology
Good Entry OPEN
Position
$2.50 Calls
July 17, 2026
Entry
$0.90
Jan 21, 2026
Catalyst
Phase 3 Futility
Q1 2026 (Mar 31)
CONT Score
55
Moderate
Break Even
$3.40
Max Buy
$0.99
Live ENR
--
Eftilagimod alfa (efti) + Keytruda
1L Non-Small Cell Lung Cancer (NSCLC)
Why This Trade:
+ First-in-class LAG-3 therapy with differentiated MHC Class II mechanism
+ Strong Phase 2 data: 32.9-month mOS vs 22.0 historical benchmark
+ Dr. Reddy's $369M deal validates asset value
+ Fast Track designation for lung cancer
! Risk: Futility analysis has 80%+ pass rate—lower binary volatility expected
CRMD Infectious Disease
Good Entry OPEN
Position
$8.00 Calls
Aug 21, 2026
Entry
$1.40
Jan 21, 2026
Catalyst
Phase 3 Data
Q2 2026 (Jun 30)
CONT Score
90
High
Break Even
$9.40
Max Buy
$1.54
Live ENR
--
REZZAYO (rezafungin)
Prophylaxis of Fungal Infections
Why This Trade:
+ Already FDA-approved for treatment (2023)—lower-risk label expansion
+ Profitable company with $310M FY2025 revenue—no dilution risk
+ 21.6% short interest creates squeeze potential on positive data
+ Orphan drug + Fast Track designations
! Risk: Aggressive trial design (monotherapy vs multi-drug SOC)

This is the level of detail you get with every trade alert.

Entry price, break even, buy zones, ENR scores, thesis reasoning, risk factors, and CONT scores—all updated in real-time.

What is CONT Score?

Continuation Score—predicting post-catalyst price action

Ever watched a biotech get FDA approval only to see the stock dump 20%? That's "sell the news" in action—and it kills traders who hold through catalysts blindly.

CONT Score predicts whether a stock will continue running after a positive catalyst or get dumped immediately. It factors in what the market has already priced in.

"The approval was priced in" is how traders lose money on winning bets.

What Drives CONT Score:
+ First-in-class drug (no competition = room to run)
+ Critical unmet medical need
+ High short interest (squeeze fuel)
+ Multiple upcoming catalysts
- Stock already ran 50%+ into catalyst
- "Me-too" drug in crowded market
80+
Hold Through
50-79
Quick Exit
<50
Exit Early

What Members See in Real-Time

Entry Zone
Is it still a good entry?
Break Even
Stock price needed to profit
Live ENR
Expected return at current price
Max Buy
Don't pay more than this
Limited Time Offer

Become a Founding Member

Get full access FREE for 6 months while we build our public track record. Lock in lifetime discounts before paid tiers launch.

First 100 Members
Founding Member Access
$79/mo FREE for 6 months

Then 50% off forever ($39/mo) when paid launches

Real-time trade alerts (4-8/month)
Full thesis with ENR scores
Strike, expiry & entry price
Position sizing guidance
Exit & adjustment alerts
Top 10 stock picks for 2026
Private community access
Lifetime 50% discount

No credit card required. No spam. Cancel anytime.

Founding member spots 87 of 100 remaining
After Launch

Free vs Premium

What you'll get when paid tiers launch (Founding Members keep full access at 50% off)

Free Tier

Follow Along

Always free on Twitter & Reddit

  • Educational content & methodology
  • Trade recaps (after exit)
  • 2 stock picks (of 10)
  • Public track record
  • Real-time alerts
  • Position sizing
Follow on Twitter
Premium

Full Access

$79/mo (or $39 for Founders)

  • Real-time trade alerts (4-8/month)
  • Full thesis + ENR + probability
  • Position sizing for YOUR account
  • All 10 stock picks + reasoning
  • Exit & adjustment alerts
  • Private community
Get Free Access Now
About

Built by an Engineer

I'm an engineer who got tired of watching biotech "gurus" post wins and bury losses. So I built a system that forces accountability—starting with my own.

My background is in systematic thinking: breaking complex problems into quantifiable components, building models, and making decisions based on expected value rather than emotion.

The result: A methodology that calculates expected returns, sizes positions mathematically, and compounds edge over time. Every trade public. Every loss analyzed.

Engineer by training
Systematic by nature
"Most traders treat biotech like a casino. I treat it like an engineering problem. The math doesn't lie, and neither does my track record."
JP
Jon Powers
Founder, PowersBioStrikes
Developer API

Build with Our Catalyst Data

Access 690+ biotech catalysts via REST API. PDUFA dates, Phase 2/3 readouts, FDA designations, and our proprietary CONT scores. Perfect for quant traders, fintech apps, and research platforms.

Real-time updates JSON/REST 690+ catalysts CONT scores
Request API Access

Starting at $49/month

Ready to Trade Systematically?

Join the waitlist for early access to premium features. Follow along for free on Twitter in the meantime.